Long-term Antidepressant Drug Use Linked With Risk of Epilepsy - AJMC.com Managed Markets Network
Long-term exposure to antidepressant drugs (ADs) may increase risk of epilepsy, according to study findings published recently in Epilepsy & Behavior . Use of ADs have been steadily increasing in recent years, with findings from the National Health and Nutrition Examination Survey (2015-2018) indicating that 13.2% of US adults aged 18 years or older reported use in the past 30 days. Although these drugs have proven generally well tolerated with side effects generally mild and occuring within a week of treatment, studies have demonstrated considerable adverse events, such as metabolic syndrome, sexual dysfunction, and a possible increased risk of epilepsy. For instance, researchers noted that findings of a nested case-control study of 151,005 patients with depression using selective serotonin reuptake inhibitors or selective norepinephrine reuptake inhibitors were 2 times more likely to develop first-time seizures compared with non-use, while current use of low-dose tricyclic an...